The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses its spike (S) protein to bind to the angiotensin-converting enzyme 2 (ACE2) receptor located on the surface of host cells. The priming of the S protein is carried out by transmembrane serine protease 2 (TMPRSS2), which divides the S protein at the S1/S2 site. The expression of ACE2 in testicular tissues can increase their risk of being targeted by SARS-CoV-2. Additionally, the association of androgen receptor signaling with COVID-19 severity has also provided evidence as to why men are often at a greater risk of severe disease. Prostate cancer is one of the most prevalent types of cancer and is responsible for most cancer-related deaths in men globally. High levels of TMPRSS2 and ACE2 expression have been observed in the prostate tissue. Previous studies have reported that downregulation of ACE2 expression, along with an increase in ACE2 activity, is associated with prostate carcinogenesis. The overexpression of T...
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