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Cancer immunotherapy comprises a number of current and promising therapeutic approaches intended to eradicate tumors by activating host antitumor immunity [1,2]. FDA approval of immune checkpoint blocking (ICBs) therapies and chimeric antigen receptor (CAR)-engineered T-cell immunotherapies has significantly improved cancer treatment, but they are not effective in all cancer patients. Cancer vaccines have not yet made the same clinical impact but have preventive and therapeutic potential, alone or in combination [3], and may provide lifelong immunity against cancer recurrence, potentially becoming an integral part of future combinatorial immunotherapies [4]. Turning tumor cells into cancer killers Corresponding author Khalid Shah stated that they have worked on a simple idea, transforming cancer cells into cancer killers and vaccines. Shah is the director of the Center for Stem Cell and Translational Immunotherapy (CSTI)."Using gene engineering, we are repurposing cancer cells to ...