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The study authors explained that very high levels of HDL-C associated with dementia risk in their research were uncommon and not connected to diet, but there was a greater chance it indicated a metabolic disorder. Researchers examined 18,668 healthy older participants who were mostly over the age of 70. During an average 6.3 years of follow-up, participants with very high HDL-C (>80 mg/dL or >2.07 mmol/L) at the start of the study had a 27% higher risk of dementia compared to those with optimal HDL-C levels (for men: 40 to 60 mg/dL or 1.03–1.55 mmol/L; for women: 50 to 60 mg/dL or 1.55–2.07 mmol/L). In addition, participants who were 75 years and older demonstrated a 42% increased risk in dementia compared to those with optimal levels of HDL cholesterol. Results showed 2,709 participants had very high HDL-C at the start of the study, with 38 cases of dementia in those who were younger than 75 years with very high levels, and 101 in those 75 and older with very high levels. Go...

The study authors explained that very high levels of HDL-C associated with dementia risk in their research were uncommon and not connected to diet, but there was a greater chance it indicated a metabolic disorder. Researchers examined 18,668 healthy older participants who were mostly over the age of 70. During an average 6.3 years of follow-up, participants with very high HDL-C (>80 mg/dL or >2.07 mmol/L) at the start of the study had a 27% higher risk of dementia compared to those with optimal HDL-C levels (for men: 40 to 60 mg/dL or 1.03–1.55 mmol/L; for women: 50 to 60 mg/dL or 1.55–2.07 mmol/L). In addition, participants who were 75 years and older demonstrated a 42% increased risk in dementia compared to those with optimal levels of HDL cholesterol. Results showed 2,709 participants had very high HDL-C at the start of the study, with 38 cases of dementia in those who were younger than 75 years with very high levels, and 101 in those 75 and older with very high levels. Go...