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Sexual dysfunction is a common problem among women. Almost half of all women have persistent problems with sex, such as little or no sex drive, trouble reaching an orgasm, or pain during intercourse. Medical or Physical Conditions Heart disease, diabetes, thyroid disease, nerve conditions such as multiple sclerosis, and even simple fatigue can make sex uncomfortable or painful. They can make it hard for you to get aroused or climax during sex. Scarring from surgery or radiation treatment in your vaginal opening or in other parts of your genital area also can change your sexual experience. So can infections such as genital herpes. Other possible causes include hormonal imbalance or physical changes related to: Pregnancy (you may have sex less often or find it uncomfortable, especially during the third trimester) Childbirth (your genitals may be less sensitive, you may have had a difficult de...